Poly-ADP ribose polymerases (PARPs) are proteins that participate in the process of repairing single strand DNA breaks (SSBs). PARPs carry out surveillance in the cell and when DNA damage occurs, PARPs bind to and recognize DNA damage, setting off DNA repair pathways (Morales et al., 2014). PARP inhibitors (PARPi) block the DNA damage repair pathway, […]
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Chemistry and Biochemistry
Engineered Nanoparticles Enable Selective Gene Therapy in Brain Tumors
Inborn protective mechanisms present challenges for therapies targeting cancers of the brain. Engineered nanoparticles permit the selective delivery of CRISPR-Cas9 to glioblastoma tumors. Glioblastoma accounts for almost half of all cancerous tumors originating in the brain.1 Even with maximum safe treatment, the median survival period for patients is less than 1.5 years.2 However, survival varies […]
Computer Science and Tech
Getting the Big Picture: Satellite Altimetry and the Future of Sea Level Rise Research
Anthropogenic climate change is drastically affecting the natural processes of the Earth at unprecedented rates. Increased fossil fuel emissions coupled with global deforestation have altered Earth’s energy budget, creating the potential for positive feedback loops to further warm our planet. While some of this warming manifests through glacier melting, powerful storm systems, and rising global […]
Environmental Science
Microplastic burden in marine benthic invertebrates depends on feeding strategies
Microplastic pollution is a global issue effectively impacting all aquatic systems from the poles to tropical reefs. Current emission patterns project to around 35 – 98 metric tons of annual microplastic emission by 2030. Yet, this may only be an underestimation, as our current understanding of microplastic concentrations based on traditional sampling practices overlooks smaller […]
Math and Physics
Coronal Bright Points As a Solution to the Sun’s Coronal Heating Problem
As the star closest to the planet we call home, the Sun is heavily researched for its impact on the Earth and as a model for the dynamics of stars further out. One of the most prominent and vexing questions in modern helio science is the coronal heating problem. Our common sense and everyday experiences […]
Psychology and Neuroscience
The Dark Side of Antibiotics
Unveiling the Potential of PGCCs in Future Cancer Treatments
Poly-ADP ribose polymerases (PARPs) are proteins that participate in the process of repairing single strand DNA breaks (SSBs). PARPs carry out surveillance in the cell and when DNA damage occurs, PARPs bind to and recognize DNA damage, setting off DNA repair … Read Full Article about Unveiling the Potential of PGCCs in Future Cancer Treatments
Orchid Species’ Infidelity Challenges Biological Immutability
From researchers to botanists, the pervasive method of plant identification has relied heavily on the observation of physical characteristics. The outward appearance of an organism, or phenotype, is determined in large part by genotype, an organism’s genetic … Read Full Article about Orchid Species’ Infidelity Challenges Biological Immutability
The Dark Side of Antibiotics
Antibiotics are medications that fight infections caused by bacteria. But they can also lead to mental health issues, such as anxiety and depression, later in life. The discovery of antibiotics was one of the greatest medical advances of the 20th century. … Read Full Article about The Dark Side of Antibiotics